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 |
Complex Non-linear Biodynamics in Categories, Higher Dimensional Algebra and Łukasiewicz–Moisil Topos: Transformations of Neuronal, Genetic and Neoplastic Networks
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Complex Non-linear Biodynamics in Categories, Higher Dimensional Algebra and Łukasiewicz–Moisil Topos: Transformations of
Neuronal, Genetic and Neoplastic Networks
I. C. Baianu, R. Brown, G. Georgescu and J. F. Glazebrook
Abstract A categorical, higher dimensional algebra and generalized topos framework for Łukasiewicz–Moisil Algebraic–Logic models of
non-linear dynamics in complex functional genomes and cell interactomes is proposed. Łukasiewicz–Moisil Algebraic–Logic models
of neural, genetic and neoplastic cell networks, as well as signaling pathways in cells are formulated in terms of non-linear
dynamic systems with n-state components that allow for the generalization of previous logical models of both genetic activities and neural networks.
An algebraic formulation of variable ‘next-state functions’ is extended to a Łukasiewicz–Moisil Topos with an n-valued Łukasiewicz–Moisil Algebraic Logic subobject classifier description that represents non-random and non-linear network
activities as well as their transformations in developmental processes and carcinogenesis. The unification of the theories
of organismic sets, molecular sets and Robert Rosen’s ( M,R)-systems is also considered here in terms of natural transformations of organismal structures which generate higher dimensional
algebras based on consistent axioms, thus avoiding well known logical paradoxes occurring with sets. Quantum bionetworks,
such as quantum neural nets and quantum genetic networks, are also discussed and their underlying, non-commutative quantum
logics are considered in the context of an emerging Quantum Relational Biology.
Keywords adjoint functors and dynamically analogous systems - biogroupoids and organismal development - biological principles - nuclear equivalence and cell differentiation - categories - n-valued logics and higher dimensional algebra in neuroscience and genetics - cognitive and anticipatory processes - learning and quantum wave-pattern recognition - colimits - limits and adjointness relations in biology - generalized (M,R)-systems - neuro-categories and consciousness - quantum automata and relational biology - quantum bionetworks and their underlying quantum logics - quantum computers
References
Abbott, E. A. (1884) Flatland: A Romance of Many Dimensions, Dover, London
|
|
Al-Agl, , Brown, F. R., Steiner, R. (2002) "Multiple Categories: The Equivalence Between a Globular and Cubical Approach" Advances in Mathematics 170: 71-118
|
|
Anandan, J. (1992) "The Geometric Phase" Nature 360: 307-313
|
|
Aof, M.E.-S.A., Brown, R. (1992) "The Holonomy Groupoid of a Locally Topological Groupoid" Topology and its Applications 47: 97-113
|
|
Arbib, M. A., Manes, E. G. (1986) Algebraic Approaches to Program Semantics, Springer-Verlag, Berlin
|
|
Baader, F., Nipkow, T. (1998) Term Rewriting and All That, Cambridge University Press, Cambridge UK
|
|
Baars, B. J. (1988) A Cognitive Theory of Consciousness, Cambridge University Press, Cambridge UK
|
|
Baez, J.: 1995, ‘This Week’s Find in Mathematical Physics’, week 3,
http://obswww.unige.ch/lbartho/TWF/week53.html
|
|
Baianu, I. C., J. F. Glazebrook, and G. Georgescu: 2004, ‘Categories of Quantum Automata and N-Valued Łukasiewicz Algebras in Relation to Dynamic Bionetworks, (M,R)-Systems and Their Higher Dimensional Algebra’, Abstract and Preprint of Report:
http://www.ag.uiuc.edu/fs401/QAuto.pdf; and
http://www.medical–papers.com/quantum+automata+math+categories+baianu/ |
|
Baianu, I. C., R. Brown and J. F. Glazebrook: 2005, ‘Quantum Algebraic Topology and Field Theories’, (in preparation):
http://www.ag.uiuc.edu/fs401/QAT.pdf
|
|
Baianu, I. C., Marinescu, M. (1968) "Organismic Supercategories: Towards a Unified Theory of Systems" Bulletin of Mathematical Biophysics 30: 148-165
|
|
Baianu, I. C.: 1969, Theoretical and Experimental Models of Carcinogenesis, MSc. Thesis, Medical Biophysics Department & School of Physics, University of Bucharest
|
|
Baianu, I. C. (1970) "Organismic Supercategories: II. On Multistable Systems" Bulletin of Mathematical Biophysics 32: 539-561
|
|
Baianu, I. C. (1971a) "Organismic Supercategories and Qualitative Dynamics of Systems" Ibid. 33: 339-353
|
|
Baianu, I. C.: 1971b, ‘Categories, Functors, Quantum Automata and Quantum Computation’, in P. Suppes (ed.), Proceedings of the 4th Intl. Congress LMPS, Bucharest
|
|
Baianu, I. C. (1971c) "Resonant Transfer of Energy in Oncogenesis" An. Univ. Bucharest – Physics 20: 56-58
|
|
Baianu, I. C. (1972) "Energetic and Categorical Considerations in EEG Interpretation’" An. Univ. Bucharest – Physics 21: 60-67
|
|
Baianu, I. C. (1973) "Some Algebraic Properties of (M,R)-Systems" Bulletin of Mathematical Biology 35: 213-217
|
|
Baianu, I. C., Scripcariu, D. (1974) "On Adjoint Dynamical Systems" Bulletin of Mathematical Biology 36: 356-364
|
|
Baianu, I. C., Marinescu, M. (1974) "A Functorial Construction of (M,R)-Systems’" Revue Roumaine de Mathematiques Pures Et Appliquees 19: 388-391
|
|
Baianu, I. C. (1977) "A Logical Model of Genetic Activities in Łukasiewicz Algebras: The Non-linear Theory" Bulletin of Mathematical Biology 39: 249-258
|
|
Baianu, I. C. (1980) "Natural Transformations of Organismic Structures" Bulletin of Mathematical Biology 42: 431-446
|
|
Baianu, I. C.: 1983, ‘Natural Transformation Models in Molecular Biology’, Proceedings of the SIAM Natl. Meet., Denver, CO.; Eprint:
http://cogprints.org/3675/; http://cogprints.org/3675/01/Naturaltransfmolbionu6.pdf.
|
|
Baianu, I. C. (1984) "A Molecular-Set-Variable Model of Structural and Regulatory Activities in Metabolic and Genetic Networks" FASEB Proceedings 43: 917
|
|
Baianu, I. C.: 1987a, ‘Computer Models and Automata Theory in Biology and Medicine’ in M. Witten (ed.), Mathematical Models in Medicine, vol. 7., Pergamon Press, New York, 1513-1577; CERN Preprint No. EXT–2004–072:
http://doc.cern.ch//archive/electronic/other/ext/ext-2004-072.pdf.
|
|
Baianu, I. C.: 1987b, ‘Molecular Models of Genetic and Organismic Structures’, in Proceed. Relational Biology Symp., Argentina; CERN Preprint No. EXT–2004–067,
http: //doc.cern.ch/archive/electronic/other/ext/ext-2004-067/ MolecularModelsICB3.doc.
|
|
Baianu, I. C.: 2004a, ‘Quantum Interactomics and Cancer Mechanisms’, Preprint No. 00001978– http: bioline.utsc.utoronto.ca/archive/00001978/01/QuantumInteractomicsInCancer–Sept13k4E–cuteprt.pdf; http://bioline.utsc.utoronto.ca/archive/00001978/
|
|
Baianu, I. C.: 2004b, ‘Quantum Nano–Automata (QNA): Towards Microphysical Measurements’, CERN Preprint No. EXT–2004–125, http://documents.cern.ch/cgi-bin/setlink?base=preprint& categ=ext & id=ext-2004-125
|
|
Baianu, I. C. and V. Prisecaru: 2004, ‘Complex Systems Biology Modeling of Cancer Cell Cycling’, Preprint: arXiv q-bio/0406045.
|
|
Baianu, I. C.: 2006, ‘Robert Rosen’s Work and Complex Systems Biology’, Axiomathes, (in this volume) |
|
Bak, A., R. Brown, G. Minian and T. Porter: 2004,‘ Global Actions, Groupoid Atlases and Related Topics’,
http://citeseer.ist.psu.edu/bak00global.html
|
|
Bell, A., Holcombe, M. (1996)
"Computational Models of Cellular Processing" In: Cuthbertson, R.,
Holcombe, M.,
Paton, R. eds. , Computation in Cellular and Molecular Biological Systems, World Scientific, Singapore
|
|
Birkhoff, G. (1948) Lattice Theory, American Mathematical Society, New York
|
|
Bourbaki, N. (1964) Eléments de Mathématique, Livre II, Algébre, Hermann, Editor, Paris
|
|
Brown, R. (1987) "From Groups to Groupoids a Brief Survey" Bulletin of the London Mathematical Society 19: 113-134
|
|
Brown, R., P. J. Higgins, and R. Sivera: 2005, Non-Abelian Algebraic Topology, (new book in preparation)
|
|
Brown, R. (2004) "Crossed Complexes and Homotopy Groupoids as Non-commutative tools for Higher Dimensional Local-to-Global Problems" Proceedings of the Fields Institute Workshop on Categorical Structures for Descent, Galois Theory, Hopf Algebras and Semiabelian
Categories, Fields Institute Communications 43: 101-130
|
|
Brown, R., Heyworth, A. (2000) "Using Rewriting Systems to Compute left Kan Extensions and Induced Actions of Categories" Journal of Symbolic Computation 29: 5-31
|
|
Brown, R., Porter, T. (2003a) "‘The Intuitions of Higher Dimensional Algebra for the Study of Structured Space’" Revue de Synthèse 124: 174-203 Comment: Seminar at the series of G. Longo Géometrie et Cognition, École Normale Supérieure, May 2001
|
|
Brown, R. and T. Porter: 2003b, ‘Category Theory and Higher Dimensional Algebra: Potential Descriptive Tools in Neuroscience’,
in N. Singh (ed.) Proceedings of the International Conference on Theoretical Neurobiology, Delhi, February 2003, National Brain Research Centre, Conference Proceedings 1, 80–92
|
|
Brown R., R. Paton and T. Porter: 2004, ‘Categorical Language and Hierarchical Models for Cell Systems’, in R. Paton, H. Bolouri,
M. Holcombe, J. H. Parish and R. Tateson (eds.), Computation in Cells and Tissues – Perspectives and Tools of Thought, Natural Computing Series, Springer-Verlag, pp. 289–303
|
|
Buneci, M.: 2003, Groupoid Representations, UTJ, Bucharest
|
|
Carnap, R. (1938) The Logical Syntax of Language, Harcourt, Brace and Co, New York
|
|
Cordier, J.-M., Porter, T. (1989) Shape Theory – Categorical Methods of Approximation, Ellis Horwood, Chichester, UK
|
|
Dampney, C. N. G., Johnson, M. (1994)
"On the Value of Commutative Diagrams in Information Modelling" In: Nivat, eds. , Springer Workshops in Computing, Springer, London, pp 47-60
|
|
Jong, H., Page, M. (2000)
"Qualitative Simulation of Large and Complex Genetic Regulatory Systems" In: Horn, W. eds. , Proceedings of the Fourteenth European Conference on Artifical Intelligence, ECAI 2000, IOS Press, Amsterdam, pp 141-145
|
|
Jong, H., Geiselmann, J., Thieffry, D. (2003)
"Qualitative Modeling and Simulation of Developmental Regulatory Systems" In: Kumar, S.,
Bentley, P. J. eds. , On Growth, Form, and Computers, Academic Press, London, pp 109-143
|
|
Jong, H. (2005) "Qualitative Dynamics of Complex Genetic Regulatory Systems" Bulletin Mathematical Biology 66: 235-257
|
|
Dioguardi, N. (1995) Fegato a Piu Dimentioni, Etas Libri, RCS Medecina, Milan
|
|
Edelman, G. (1992) Brilliant Air, Brilliant Fire – On the Matter of the Mind, Basic Books, New York
|
|
Edelman, G. (1989) The Remembered Present, Basic Books, New York
|
|
Edelman, G., Tononi, G. (2000) A Universe of Consciousness, Basic Books, New York
|
|
Ehresmann, A. C., Vanbremeersch, J.-P. (1987) "Hierarchical Evolutive Systems: A Mathematical Model for Complex Systems" Bulletin of Mathematical Biology 49: 13-50 Comment: (For a full list of their work see: http://perso.wanadoo.fr/vbm-ehr/Ang/Publi2T.htm)
|
|
Ehresmann, A. C. and J.-P. Vanbremeersch: 2003, A Categorical Model for Cognitive Systems up to Consciousness, Ibid. (Brown and Porter, 2003b)
|
|
Ehresmann, A. C., Vanbremeersch, J.-P. (2002) "Emergence Processes up to Consciousness Using the Multiplicity Principle and Quantum Physics" AIP Conference Proceedings 627: 221-233
|
|
Ehresmann, C. (1965) Catégories et Structures, Dunod, Paris
|
|
Ehresmann, C. (1966) "Trends Toward Unity in Mathematics" Cahiers de Topologie et Géometrie Differentielle 8: 1-7
|
|
Ehresmann, C. (1967) "Sur les Structures Algebriques" C.R.A.S. Paris 264: 840-843
|
|
Eilenberg, S., MacLane, S. (1945) "The General Theory of Natural Equivalences" Transactions of the American Mathematcal Society 58: 231-294
|
|
Fisher, M. J., Malcolm, G., Paton, R. C. (2000) "Spatio-Logical processes in Intracellular Signaling" Biosystems 55: 83-92
|
|
Gadducci, F. and U. Montanari: 1995, ‘Enriched Categories as Models of Computation’, in A. De Santis (ed.), Proceed. Fifth Italian Conference on Theoretical Computer Science, World Scientific, 20–42
|
|
Georgescu, G., Popescu, D. (1968) "On Algebraic Categories" Revue Roumaine De Mathematiques Pures Et Appliquees 13: 337-342
|
|
Georgescu, G., Vraciu, C. (1970) "On the Characterization of Łukasiewicz–Moisil Algebras" Journal of Algebra 16: 486-495
|
|
Georgescu, G.: 2006, ‘N–valued Logics and Łukasiewicz–Moisil Algebras’, Axiomathes (in this volume)
|
|
Girault, F.: 1997, ‘Formalisation en Logique Lineáire du Fonctionnement des Réseaux de Petri’, Thèse, LAAS, Université Paul
Sabatier Toulouse
|
|
Goguen, J.: 1999, ‘An Introduction to Algebraic Semiotics with Application to User Interface Design’, in Computation for Metaphor, Analogy and Agents, Lecture Notes in AI, No. 1562, Springer
|
|
Goguen, J., Malcolm, G. (2000) "A Hidden Agenda" theoretical Computer Science 245: 55-101
|
|
Gudder, S. (2004)
"Noncommutative Probability and Applications" In: Rao, M. M. eds. , Real and Stochastic Analysis – New Perspectives, Birkhäuser, Boston, Basel, Berlin, pp 199-238
|
|
Hilbert, D., Ackerman, W. (1927) Grunzüge der theoretischen Logik, Springer, Berlin
|
|
Hughes, K. H., Macdonald, J. N. (2002) "Boltzmann Wavepacket Dynamics on Periodic Molecular Potential Functions" Physical Chemistry Chemical Physics 2: 4267-4273
|
|
Jacob, F. and J. Monod: 1961a, ‘On the Regulation of Gene Activity’, in Frisch (ed.), Cold Spring Harbor Symposium Quantit. Biology 26, New York, 193–211
|
|
Jacob, F., Monod, J. (1961b) "Regulation of DNA Reduplication in Bacteria" Ibid. 28: 323-376
|
|
Kan, D. M. (1958) "Adjoint Functors" Transactions of the American Mathematical Society 87: 294-329
|
|
Krips, H.: 1999, ‘Measurement in Quantum Theory’, in E. N. Zalta (ed.) The Stanford Encyclopedia of Philosophy (Winter 1999 Edition)
|
|
Krsti, S., J. Launchbury and D. Pavlovic: 2001, ‘Categories of Processes Enriched in Final Coalgebras’, SLNCS 2030, Springer, 303
|
|
Lambek, J., Scott, P. J. (1986) Introduction to Higher Order Categorical Logic, Cambridge University Press, Cambridge, UK
|
|
Lawvere, F. W. (1963) "Functorial Semantics of Algebraic Theories" Proceedings of the National Academy of Sciences USA 50: 869-872
|
|
Lawvere, F. W. et al. (1966)
"‘The Category of Categories as a Foundation for Mathematics’" In: Eilenberg, S. eds. , Proc. Conf. Categorical Algebra–La Jolla, Springer-Verlag, USA,Berlin, Heidelberg and New York, pp 1-20 Comment: (1965)
|
|
Löfgren, L. (1968) "An Axiomatic Explanation of Complete Self-Reproduction" Bulletin of Mathematical Biophysics 30: 317-348
|
|
MacLane, S., Moerdijk, I. (1992) Sheaves in Geometry and Logic – A First Introduction to Topos Theory, Springer-Verlag, New York
|
|
McCulloch, W., Pitts, W. (1943) "A Logical Calculus of Ideas Immanent in Nervous Activity" Bulletin of Mathematical Biophysics 5: 115-133
|
|
Meseguer, J. (1993)
"‘A Logical Theory of Concurrent Objects and Its Relation to the MAUDE Language’" In: Agha, G.,
Wegner, P.,
Yonezawa, A. eds. , Research Directions in object oriented based concurrency, MIT Press, Cambridge MA, pp 314-390 Comment: (see also http://maude.csl.sri.com/papers/).
|
|
Meseguer, J. and U. Montanari: 1998, ‘Mapping Tile Logic into Rewriting Logic’, in F. Parisi-Presicce (ed.), Recent Trends in Algebraic Development Techniques, Springer LNCS 1376, pp. 62–91. (Available from
http://www.di.unipi.it/ugo/wadt.ps)
|
|
Mitchell, B. (1965) Theory of Categories, Academic Press, London
|
|
Paton, R. C. (1997) "Glue, Verb and Text Metaphors in Biology" Acta Biotheoretica 45: 1-15
|
|
Paton, R. C. (2002) "Process, Structure and Context in Relation to Integrative Biology" Biosystems 64: 63-72
|
|
Peruš, M, Bischof, H. (2003)
"‘Quantum Wave Pattern Recognition’" In: Chen, K. eds. , Proceedings of the 7-th Joint Conf. Information Sciences, publ. by JCIS/Assoc. for Intelligent Machinery, Durham, Cary, NC USA, pp 31-36 Comment: (e–publ. : quant-ph/0303092)
|
|
Peruš, M., Bischof, H., Kiong, L. C. (2004) "‘Quantum–Implemented Selective Reconstruction of High–Resolution Images’" Appl. Opt. 43: 6134-6138 Comment: Los Alamos preprint archive, http:arxiv.org/abs/quant-ph/0401016
|
|
Pitts, W. (1943) "The Linear Theory of Neuron Networks" Bulletin of Mathematical Biophysics 5: 23-31
|
|
Popescu, N. (1975) Abelian Categories with Applications to Rings and Modules, 2nd edn (English translation by I. C. Baianu), Academic Press, New York and London
|
|
Porter, T. (1994a) "Categorical Shape Theory as a Formal Language for Pattern Recognition" Annals of Mathematics and Artificial Intelligence 10: 25-54
|
|
Porter, T.: 1994b, ‘Can Categorical Shape Theory handle Grey Level Images?’ in Shape in Picture NATO ASI Series F, Vol. 126, Springer
|
|
Rashevsky, N. (1954) "Topology and Life: In Search of General Mathematical Principles in Biology and Sociology" Bulletin of Mathematical Biophysics 14: 317-348
|
|
Rashevsky, N. (1961) "Biological Epimorphism, Adequate Design and the Problem of Regeneration" Bulletin of Mathematical Biophysics 23: 109-113
|
|
Rashevsky, N. (1965) "The Representation of Organisms in Terms of Predicates" Bulletin of Mathematical Biophysics 27: 477-491
|
|
Rashevsky, N. (1967) "Organismic Sets and Biological Epimorphism" Bulletin of Mathematical Biophysics 29: 389-393
|
|
Rashevsky, N. (1968a) "Neurocybernetics as a Particular Case of General Regulatory Mechanisms in Biological and Social Organisms" Concepts de l’Age de la Science 3: 243-258
|
|
Rashevsky, N. (1968b) "Organismic Sets in Biology and Sociology" Bulletin of Mathematical Biophysics 30: 246-259
|
|
Rashevsky, N. (1969) "Outline of a Unified Approach to Physics, Biology and Sociology" Bulletin of Mathematical Biophysics 31: 159-198
|
|
Rashevsky, N. (1972) Organismic Sets, William Clowes & Sons, London
|
|
Rayadu, P. V.: 2003. ‘Towards an Algebra of Neural Processing of Contextual Information’, Proceedings of the International Conference on Theoretical Neurobiology, Delhi, February 2003, ibid (Brown, Porter and Paton, 2003a), pp. 110–112
|
|
Rosen, R. (1958a) "A Relational Theory of Biological Systems" Bulletin of Mathematical Biophysics 20: 245-260
|
|
Rosen, R. (1958b) "The Representation of Biological Systems from the Standpoint of the Theory of Categories" Bulletin of Mathematical Biophysics 20: 317-341
|
|
Rosen, R. (1960) "A Quantum-Thoretic Approach to Genetic Problems" Bulletin of Mathematical Biophysics 22: 227-255
|
|
Rosen, R. (1968a) "On Analogous Systems" Bulletin of Mathematical Biophysics 30: 481-492
|
|
Rosen, R. (1968b) "Recent Developments in the Theory of Control and Regulation of Cellular Processes" International Review of Cytology 23: 25-88
|
|
Rosen, R. (1971) "Some Realizations of (M,R)-Systems and Their Interpretation" Bulletin of Mathematical Biophysics 33: 303-319
|
|
Rosen, R. (1973) "On the Dynamical Realization of (M,R)-Systems" Bulletin of Mathematical Biology 35: 1-9
|
|
Rosen, R. (1991) Life Itself, Columbia University Press, New York
|
|
Rosen, R. (2000) Essays on Life Itself, Columbia University Press, New York Comment: (also 2nd Edn., 2004)
|
|
Russell, B., Whitehead, A. N. (1925) Principia Mathematica, Cambridge Univ. Press, Cambridge UK
|
|
Russell, B. (1937) Principles of Mathematics, 2, George Allen & Unwin Ltd., London
|
|
Schrödinger, E. (1945) What is Life?, Cambridge University Press, Cambridge
|
|
Stapp, H. P. (1999) "Attention, Intention and Will in Quantum Physics" Journal of Consciousness Studies 6: 143-164
|
|
Wallace, R. (2005) Consciousness: A Mathematical Treatment of the Global Neuronal Workspace, Springer-Verlag, Berlin
|
|
Zadeh, A. L. (1965) "Fuzzy sets" Information Control 8: 338-353
|
|
|
|
|
|
|