Bessel functions: applications to diffraction by helical structures
One notes also that Bessel's equation
arises in the derivation of separable solutions to Laplace's equation, and also for the Helmholtz equation in either cylindrical or spherical coordinates. The Bessel functions
are therefore very important in many physical problems involving wave propagation, wave diffraction phenomena-including X-ray
diffraction by certain molecular crystals, and also static potentials. The solutions to most problems in cylindrical coordinate systems
are found in terms of Bessel functions of integer order
(
), whereas in spherical coordinates, such solutions involve Bessel functions of half-integer orders (
).
Several examples of Bessel function solutions are:
- the diffraction pattern of a helical molecule
wrapped around a cylinder computed from the Fourier transform
of the helix in cylindrical coordinates;
- electromagnetic waves in a cylindrical waveguide
- diffusion problems on a lattice.
- vibration modes of a thin circular, tubular or annular membrane (such as a drum, other membranophone, the vocal cords, etc.)
- heat
conduction
in a cylindrical object
In engineering Bessel functions also have useful properties for signal processing and filtering noise as for example by using Bessel filters, or in FM synthesis and windowing signals.
The first example listed above was shown to be especially important in molecular
biology for the structures of helical secondary structures in certain proteins (e.g.
) or in molecular genetics for finding the double-helix
structure of Deoxyribonucleic Acid (DNA) molecular crystals with extremely important consequences for genetics, biology, mutagenesis, molecular evolution,
contemporary life sciences and medicine. This finding is further detailed in the next subsection.
Francis C. Crick (Nobel laureate in Physiology and Medicine in 1962) published in Acta Crystallographica (1952;1953a,b) concise papers on X-ray diffraction patterns of a helix and coiled coils, respectively [5,6,7] in which he showed that such patterns can be completely described by the Bessel functions defined above. Thus, the equatorial, or 0-layer, line contained diffraction intensities whose values were computed with the
Bessel function
of the first kind with
. In fact, the entire X-ray diffraction, multiple diamond-like pattern of such helices, including those of the double helical
DNA molecule, could be completely computed by means of Bessel functions of different order for each layer line; note however that there have also been occasional contenders to this analysis. In fact, these involve Fourier-Bessel series based on Bessel functions.
There are, however, marked differences between the
A- and B- DNA X-ray diffraction patterns
as shown by this web link
which makes a comparison between the images published by H.R. Wilson [15]. The Bessel function and Fourier-Bessel series analysis is however only applicable to the analysis of A-DNA patterns, whereas the X-Ray diffraction/scattering pattern of the B-DNA form is much less tractable although it is the predominant hydrated form in living cells.
The following is a web link to a 3D animation of a Watson-Crick DNA double-helix molecular model
Note also that a pairing of double helices of a DNA G-quadruplex
has also been recently discovered that might be associated with the initiation of certain cancers; the square
of the Fourier transform of such DNA G-quadruplex structures
would still result in diffraction patterns constructed from Bessel functions but the new quadruplex symmetry of the `mutated' DNA G-quadruplex
would naturally alter the overall diffraction pattern intensities.
Further details and implications for both genomic and biotechnology applications
are presented in a related entry on molecular models of DNA.
- 1
-
F. Bessel, ``Untersuchung des Theils der planetarischen Störungen'', Berlin Abhandlungen (1824), article 14.
- 2
-
Franklin, R.E. and Gosling, R.G. recd.6 March 1953. Acta Cryst. (1953). 6, 673 The Structure of Sodium Thymonucleate Fibres I. The Influence of Water Content Acta Cryst. (1953). and 6, 678 The Structure of Sodium Thymonucleate Fibres II. The Cylindrically Symmetrical Patterson Function.
- 3
-
Arfken, George B. and Hans J. Weber, Mathematical Methods for Physicists, 6th edition, Harcourt: San Diego, 2005. ISBN 0-12-059876-0.
- 4
-
Bowman, Frank. Introduction to Bessel Functions.. Dover: New York, 1958). ISBN 0-486-60462-4.
- 5
-
Cochran, W., Crick, F.H.C. and Vand V. 1952. The Structure of Synthetic Polypeptides. 1. The Transform of Atoms on a Helix. Acta Cryst. 5(5):581-586.
- 6
-
Crick, F.H.C. 1953a. The Fourier Transform of a Coiled-Coil., Acta Crystallographica 6(8-9):685-689.
- 7
-
Crick, F.H.C. 1953. The packing of
-helices- Simple coiled-coils.
Acta Crystallographica, 6(8-9):689-697.
- 8
-
Watson, J.D; Crick F.H.C. 1953a. Molecular Structure of Nucleic Acids- A Structure for Deoxyribose Nucleic Acid., Nature 171(4356):737-738.
- 9
-
Watson, J.D; Crick F.H.C. 1953b. The Structure of DNA., Cold Spring Harbor Symposia on Qunatitative Biology 18:123-131.
- 10
-
M. H. F. Wilkins, A.R. Stokes A.R. and H. R. Wilson. 1953. ``Molecular Structure of Deoxypentose Nucleic Acids'' Nature, volume 171, pages 738-740. Download the full text in PDF format.
- 11
- N. PISKUNOV: Diferentsiaal- ja integraalarvutus kõrgematele tehnilistele õppeasutustele. Kirjastus Valgus, Tallinn (1966).
- 12
- K. KURKI-SUONIO: Matemaattiset apuneuvot. Limes r.y., Helsinki (1966).
- 13
-
I.S. Gradshteyn, I.M. Ryzhik, Alan Jeffrey, Daniel Zwillinger, editors. Table of Integrals, Series, and Products., Academic Press, 2007.
ISBN 978-0-12-373637-6.
- 14
-
Spain,B., and M. G. Smith, Functions of mathematical physics., Van Nostrand Reinhold Company, London, 1970. Chapter 9: Bessel functions.
- 15
-
The X-ray patterns of A- and B- DNA forms are compared in the following linked image (courtesy of Dr. H.R. Wilson, F.R.S.)
- 16
-
Watson, G. N. A Treatise on the Theory of Bessel Functions., (1995) Cambridge University Press. ISBN 0-521-48391-3.
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As of this snapshot date, this entry was owned by bci1.