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(This is our NIR and XRD wiki's Front Page).
Vibrational and Rotational Spectroscopies
Vibrational- Rotational Spectroscopy, Fluorescence and Chemical-Hyperspectral Imaging
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DNA Structures and XRD Patterns
DNABasics29p.pdf
DNADynamics8Mb.pdf
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Figure 1. : Three DNA Molecular Configurations: A-DNA, B-DNA (fully hydrated) and Z-DNA
Figure 2. Comparison of XRD patterns of A— (left) and B—(right) DNA
Figure 3: A DNA Biochip. Can one have DNA nanocomputing?
XRD Experiment Example
Figure 4: Bragg's Law of Diffraction
Applications to Genomics, Genomic Technologies and Beyond
c-DNA arrays for genetic analysis on a chip
DNA Biochip
DNA-Quadruplex: A possible source of Cancers
Animated DNA Molecular Models and Hydrogen-Bonding in DNA
Animated molecular models allow one to visually explore the three-dimensional (3D) structure of DNA. The first DNA model is a space-filling, or [[CPK]], model of the DNA double-helix whereas the third is an animated wire, or skeletal type, molecular model of DNA. The last two DNA molecular models in this series depict quadruplex DNA that may be involved in certain cancers<ref>
http://www.phy.cam.ac.uk/research/bss/molbiophysics.php</ref><ref>
http://planetphysics.org/encyclopedia/TheoreticalBiophysics.html</ref>. The first CPK model in the second row is a molecular model of hydrogen bonds between water molecules in ice that are broadly similar to those found in DNA; the hydrogen bonding dynamics and proton exchange is however very different by many orders of magnitude between the two systems of fully hydrated DNA and water molecules in ice. Thus, the DNA dynamics is complex, involving nanosecond and several tens of picosecond time scales, whereas that of liquid ice is on the picosecond time scale, and that of proton exchange in ice is on the millisecond time scale; the proton exchange rates in DNA and attached proteins may vary from picosecond to nanosecond, minutes or years, depending on the exact locations of the exchanged protons in the large biopolymers. The simple [[harmonic oscillator]] 'vibration' in the third, animated image of the next gallery is only an oversimplified dynamic representation of the longitudinal vibrations of the DNA intertwined helices which were found to be [[anharmonic]] rather than harmonic as often assumed in quantum dynamic simulations of DNA.
Image Gallery
Close-packed (CPK) molecular model
Hydrogen bonds in DNA
Planar Nanostructures built with DNA molecules
Carboxysome 3D-Structure Reconstruction
Fluorescence Image of a Dividing Cell
A- , B- and Z- DNA Configurations
c-DNA arrays"'
DNA-Quadruplex: A possible source of Cancers
Web Links listing:
NIR Imaging of Single Cancer Cells in Human Breast Tumors
http://cdsweb.cern.ch/record/768090/files/SinglecancerCellFTNIRFCSIR.doc
Baianu,I C; Korban, S S; Costescu, D; You, T; Lozano, P; Hofmann, N E. 2004a. Fourier Transform Near Infrared Microspectroscopy, Infrared Chemical Imaging, High-Resolution Nuclear Magnetic Resonance and Fluorescence Microspectroscopy Detection of Single Cancer Cells and Single Viral Particles . CERN Preprint- EXT-2004-069: Single Cancer Cells from Human tumors are being detected and imaged by Fourier Transform Infrared (FT-IR), Fourier Transform Near Infrared (FT-NIR)Hyperspectral Imaging and Fluorescence Correlation Microspectroscopy.
http://radiology.rsna.org/content/248/3/925.full.pdf
http://www.encyclopedia.com/doc/1G1-113813479.html
http://www.medscape.com/viewarticle/574914_3
PlanetPhysics.org: http://planetphysics.org/
NIR Analyses of Amino Acid Residues in Proteins
Books
Spectroscopy.: http://planetphysics.org/?op=getobj&from=books&id=277
Spectroscopy and Applications Book: http://planetphysics.org/?op=getobj&from=books&id=312
Spectroscopy Principles, Techniques and Applications http://planetphysics.org/?op=getobj&from=books&id=294
2D-FT NMRI and Spectroscopy
http://planetphysics.org/?op=getobj&from=books&id=212
Articles
"Principles of NIR Spectroscopy" (VIP) : http://planetphysics.org/?op=getobj;from=objects;id=410
Applications to Biotechnology and Medicine: http://cdsweb.cern.ch/record/768087/files/ApplBiotechnology8NU.doc
Novel Techniques and Their Wide Applications to Health Foods, Medical and Agricultural Biotechnology in Relation to Policy Making on Genetically Modified Crops and Foods / Baianu, I C ; Prisecaru, V I ; Lozano, P ; Lin, H C. : Abstract: Selected applications of novel techniques in Agricultural Biotechnology, Health Food formulations and Medical Biotechnology are being reviewed with the aim of unraveling future developments and policy changes that are likely to open new markets for Biotechnology and prevent the shrinking or closing of existing ones. [...]
EXT-2004-066. - 2004. - 38 p.
Near Infrared Microspectroscopy, Fluorescence Microspectroscopy, Infrared Chemical Imaging and High Resolution Nuclear Magnetic Resonance Analysis of Soybean Seeds, Somatic Embryos and Single Cells / Baianu, I C ; Costescu, D ; Hofmann, N E ; Korban, S S ; Lozano, P ; You, T
Novel methodologies are currently being developed and established for the chemical analysis of soybean seeds, embryos and single cells by Fourier Transform Infrared (FT-IR), Fourier Transform Near Infrared (FT-NIR) Microspectroscopy, Fluorescence and High-Resolution NMR (HR-NMR). [...]
EXT-2004-068. - 2002. - 4 p.
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